Efficacy of perampanel for epileptic seizures and daily behavior in a patient with Leigh syndrome: A case report

BackgroundLeigh syndrome (LS) is a mitochondrial disorder that shows abnormal basal ganglia lesion and psychomotor regression. Although vitamins have been used for LS, we not found any effective drug.Case presentationA 26-year-old man who showed delay short stature at the age of 1 year was diagnosed with LS according to results cerebrospinal fluid high signal intensity in bilateral striatum on T2-weighted magnetic resonance imaging. He demonstrated breathing disorders, but progression very slow. His symptoms suddenly worsened 24 years after acute epididymitis. epileptic seizures simultaneously his activities daily living (ADL) significantly worsened. Several antiepileptic drugs were ineffective, suppressed by low dose perampanel ADL improved.Conclusion discussionOur case low-dose could be drug improvement patients LS.